Established as St. Anna's School on 1 August 1879 at Middle Road. Renamed St. Anthony's Boys' and Girls' School in 23 February 1886. Relocated to Victoria Street in November 1893 as St. Anthony's Boys' School. Became a primary school in 1961 when all secondary school classes were shifted to St Joseph's Institute. Relocated to current site in May 1992 as co-educational St. Anthony's Primary School. Upgrading works completed in May 2002.